Premenstrual dysphoric disorder.

If PMS hormone levels are not to blame for the majority of the symptoms, then serotonin, or the lack of it, may be. Serotonin is a compound that helps to transmit signals among nerve endings in the brain and body and is believed to play an important role in the regulation of mood, sleep, sexuality and appetite. Studies have shown that women who suffer from the most severe form of the PMS blues (premenstrual dysphoric disorder) have lower levels of serotonin circulating in the blood stream.

If you visited your doctor, because you were concerned about the way that PMS symptoms were affecting your quality of life, your relationships, your job, etc., he may have recommended or even prescribed an anti-depressant known as a Selective Serotonin Re-uptake Inhibitor or SSRI. You are probably more familiar with the brand names Celexa, Zoloft, Prozac and Paxil. Rather than focusing on changing PMS hormone levels, these drugs focus on allowing the body to use serotonin more efficiently.

Mostly because numerous unwanted side effects are associated with SSRI usage, researchers have investigated the effects of natural substances used by the body to create serotonin, thus, increasing the levels of serotonin circulating in the blood stream. So far, 5-HTP has yielded the most promising results. Some study participants have seen even better results than they did when using an SSRI.